Camptothecin-based nanodrug delivery systems
نویسندگان
چکیده
منابع مشابه
Camptothecin-based nanodrug delivery systems
The drug camptothecin has a wide range of antitumor effects in cancers including gastric cancer, rectal and colon cancer, liver cancer, and lung cancer. Camptothecin-based drugs inhibit topoisomerase 1 (Topo 1), leading to destruction of DNA, and are currently being used as important chemotherapeutic agents in clinical antitumor treatment. However, the main obstacle associated with cancer thera...
متن کاملRevolutionary Impact of Nanodrug Delivery on Neuroscience
Brain research is the most expanding interdisciplinary research that is using the state of the art techniques to overcome limitations in order to conduct more accurate and effective experiments. Drug delivery to the target site in the central nervous system (CNS) is one of the most difficult steps in neuroscience researches and therapies. Taking advantage of the nanoscale structure of neural ce...
متن کاملFormulation and Optimization of Mucoadhesive Nanodrug Delivery System of Acyclovir
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infections, with an oral bioavailability of only 10-20% [limiting absorption in gastrointestinal tract to duodenum and jejunum] and half-life of about 3 h, and is soluble only at acidic pH (pKa 2.27). Mucoadhesive polymeric nanodrug delivery systems of acyclovir have been designed and optimized using 2(3) full factori...
متن کاملNanodrug delivery in reversing multidrug resistance in cancer cells
Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential factors for MDR includes enhanced drug detoxification, decreased drug uptake, increased intracellular nucleophiles levels, enhanced repair of drug induced DNA damage, overexpression of drug transporter such as P-glycoprotein...
متن کاملNew drug delivery systems based on polymeric silk fibroin
Nowadays, design and synthesis of efficient drug delivery systems are of vital importance in order to optimize the efficacy of therapeutics and reducing side effects. So far, many drug delivery systems have been designed, among them, natural polymer-based systems have attracted the most attention. Silk fibroin (SF) as a natural polymer have several unique properties including excellent biocompa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Biology & Medicine
سال: 2017
ISSN: 2095-3941
DOI: 10.20892/j.issn.2095-3941.2017.0099